As with any horn loaded subwoofer, stacking so the horn mouths couple generally produces the best results. Increasing the size of the mouth by coupling (generally 4 boxes or more) will improve your low frequency cutoff, efficiency, and directivity.
Labs are pretty good as a single box, very good with two, but become a religious experience when you get a block of 4 or more going.
When I use just two boxes per side, I've tried them vertically (mouths down) and horizontally, one on top of another. I haven't really been able to tell a noticeable difference between the two configs. The setup in the photo doesn't seem very practical for live use, unless you're throwing them under a short stage or something.
As always, YMMV.
-JB