It is just a personal preference, but I prefer that the speakers start clipping at about the same time as the VU meters on the mixer start tickling the red.
As Tim said-I hope you do not mean actual VU meters.
I know it is "proper" to have everything in the system clip at the same time (to have the most dynamic range), but I disagree with that concept.
And others will disagree-but here is my reason.
I would prefer the amps to "run out of gas" 6dB before everything else in the system.
The "problem" with everything clipping at the same time means that it will sound REALLY REALLY bad all of a sudden-with everything clipping at once).
If the amps clip a bit earlier, then you will have a bit of "fuzz" to the sound (assuming the amps clip gracefully-not all do), before it get really bad (with everything clipping at the same time).
The other problem with trying to use the meters on the console to give an idea of how far you are away from clipping, is that many conosles do not have meters that go all the way to clip.
They may go to +10 or so, then have the clip LED (which may be at +24dBu.
That gives a range of 14dB (give or take) that you have NO idea how loud it really is.
So the whole idea of the meters giving you an idea is out the window.