I just finished my first set of DR250's, which is Bill's full range cab design using a 10" driver and piezo line arrays. They sound fantastic, will play louder and sound better than most 15/1 reflex boxes and use 1/2 the power amp wattage or less. The Tuba subs are very nice, I think that the T24 is the best sub for a small but scalable system, I'm finishing my first 4 now and like you I'm thinking about doing 4 more.
I'd really recommend that you give the DR250 a try, you won't be disappointed. Two per side with four T24's per side would be a great match for a DJ system. These are very difficult cabinets to build though. If your builder isn't up to tackling them, Bill has an Omni10 design that is a more traditional horn loaded box using two 10's and the piezo line arrays. It will get a similar response to the DR250, but requiring two 10's instead of one.
People turn their nose up at piezo tweeters, but if you haven't heard them in a line array you don't know how good they can sound. You can use ribbon or other high-end tweeters, but in these cabs the piezos work just as well and need no crossover network.
One thing you should experiment with, the Tubas have a very smooth response up to 200hz. Try crossing them over at 150hz - 160hz, letting them carry more of the low end punch. Are you using any kind of DSP or RTA? You do need to EQ the subs a bit, 60hz +3db and 100hz -3db will get you in the ballpark.