If you intend to use powered loudspeakers, which accept line-level audio, then you need 2-conductor shielded cable. The source device should have a balanced output and the powered loudspeakers should have balanced inputs.
West Penn 292 is one good brand/model
If the cable is run in plenum space(s), use West Penn 25292B
I strongly suggest you read up on sound system design and installation. You can google (but be aware that there is a good amount of misinformation out there), you can search here on PSW and you can read the Study Hall (now called LSI University) articles here as a start.