Yes, I have done similar when there was a possibility such as an outdoor stage or a building with concrete slab.
HOWEVER, in Chicago, this is often not a possibility because there is either a basement below or just all wood joist contruction. So no slab that is available to connect with.
Still I will have to come up with something reasonable. Perhaps I start with selecting 15" or 12" sub drivers that are optimized for a compact box.
Any suggestions for such a driver?
One of the club installs I did back in the mid 80's was upstairs in an old ice packing plant. When the dance floor was packed the whole floor moved around. What we did was build a heavy console for the turntables and mixer and suspended it from the ceiling joists with all-thread.
Successfully using turntables many times takes some creative out of the box thinking for sure.
We used isolation damping on the turntables as well for the sonic feedback once things were decoupled from the building sway. We used layers of 1" MDF sitting on latex foam pads which worked well.
Decoupling and mass are your friend.