Rooms with low ceilings are difficult. What it really calls for is a cluster + distributed system.
The cluster provides a wide bandwidth source that ears are drawn towards, and the distributed speakers disseminate equal sound pressure level throughout the room. Like Tom said, the distributed speakers (typically 8" co-axial in a sealed enclosure,
like these, or a surface-mount enclosures
like these) need to be electronically delayed from the cluster, about every 20' feet, so that the sound from each distributed speaker is synchronized with the acoustic signal coming from the cluster. (These speakers provide a great deal of intelligibility for speech, but limited bass response.)
So, if your space is 80' deep, then it would have 4 distributed speaker zones. The 1st zone would not have any delay. The 2nd zone would be delayed approximately 20ms (milliseconds). The 3rd zone would be delayed approximately 40ms, and the 4th zone would be delayed 60ms. Each zone requires its own power amplifier. While you could probably buy all the components and eventually install a system like this, most of these components are not available to the consumer, and I recommend working with a contractor.