X-dante is limited to 32ch while aes50 offers 48ch so depending on your setup....
Another limitation is that you can only remotely control the preamps through aes50 and not by using dante.
In my current test setup I have three x32 all connected via aes50 and then each of them have different option cards installed, x-dante, x-wsg and x-live. Pretty cool setup if you ask me....
The shop i'm working out of now has X32/M32 mixers for littler stuff and QL1/QL5 and RIOs for bigger-ish stuff. All our 32s have Dante cards and i have used them with our RIO boxes several times using RIO Remote to control the HeadAmps. Works just fine.
I've only rarely used the AES50 ports and usually had some head scratching moments as a result. But i do like the idea of using them to essentially gain another card slot with a X32 Core. Especially since ours are kinda falling into disuse.