To me, Bill's cabinets seemed aimed at local bands with no money, and no trucks/road crew. While I have never heard any of them, I have looked at the site and read the forums, and have come to the conclusion that none of those designs would suit what I would call PRO PA.
For me, even the smallest PA company has a van or trailer, and owns a handtruck, so a large heavy subwoofer is not a problem. While I can appreciate smaller and lighter subs, there is only so small and so light you can go. Same with horns. A piezo or small 4X10 horn is only going to do so much, before you need to step up into a real driver/horn combination.
One of the big problems with DIY, and not just with Bill's stuff, but all DIY, is that a lot depends on the skills of the builder, and the quality of the materials, components, etc. You can have a great design like a LAB SUB, and if the builder uses crappy wood, is sloppy with measurements and joints, etc, it will not sound as good as it could.
Now don't get me wrong, I like DIY projects. In fact, I still build most of my own cabinets. But I don't build them to save money, I build them because I could not find exactly what I was looking for in a production box. My boxes cost me more than comparable boxes from a reputable manufacturer, and sound about the same, but they were designed to fit specific requirements, not to save money.
While you don't have to spend a ton of money to get decent quality sound, a box made from 1/2" wood loaded with mid level drivers is only going to go so far.