Bad idea really, will probably muddy the sound if anything.
If that's what's already in your inventory then the only way round it I could see would be by using a DSP or active crossover to run them in different frequency bands, i.e. sub and mid bass/kick bins.
Not sure whether you can bypass the internal crossovers as I've never used these, also no idea how they will sound for the same reason, but when you see 15s and 18s in the same rig this is how it will usually be done.
EDIT: a quick glance at the QSC website shows that all the cabs accept a full range input (i.e. so it can be band limited externally) so in theory this would work. They don't include anything as useful as a frequency reponse plot so not sure how well it would work in practice, although from the frequency specs given the 18 appears to go lower than the 15, as you'd expect.
Failing that the only other thing I can think of is getting rid of the 18s, buying four 15s and using those where you'd use 2 18s before, should go as low and be louder. Maybe buy another 2 15s for the big gigs to give you six. Or just buying more 18s and using those everywhere.
This could be rather good actually, anyone out there running a four way HPR rig?
(side note, I'd expect the 12" mid tops to work better in this config than the 15" ones, as they wouldn't have to deal with as much mid range signal)