I have built about 30 labs and have 18 in our rental inventory, we have gone through a fair ammount of drivers over the years. We very rarely lose drivers on a typical club show, and never with a band / live setup.
Where we do loose drivers is large outdoor festivals and DJ events. Specifically with electronic music.
In the beginning when we first started building them it was air leaks. The odd driver was over excurting, cones were tearing, spiders were seperating, voice coils were bottoming etc. After the first couple boxes we had it down and that problem disapeared.
Since then it's almost always burnt voice coils, usually on events where the system runs for 16+ hours. Our only real solution for this has been to try and do 1 large stack and cycle groups of subs out durring the non-headliner slots so they have a chance to cool down.
Lab's definatley aren't indestructable but after a bit of practice and knowing thier limits they are as reliable as any other sub.
Jeremy