It's not possible to answer your question with enough precision to make it useful with that data. EAW has published the measured output of that loudspeaker spherically such that you could put this measurement data in an acoustic prediction program along with your room's geometry and the absorption/diffusion characteristics and derive a reasonable answer.
The problem with that is it would likely cost more to have someone do this for you than the budget would reasonably allow given the modest requirements you appear to have. Therefore, the thing to do is try it. This will still require somewhat of a budget as it will need to be flown safely and moved a bit until you have the best sounding result. Generally, you want a wide dispersion loudspeaker such as the LA325 to be in front of the stage and, as you mentioned, angled downward. The downward angle is usually best when the cabinet is facing directly at the last few rows of seating.
If you do choose to do something fancy such as bringing someone in to do the acoustic prediction, it is very possible that you'll find another loudspeaker type will be a better fit. If possible, it's better not to decide on a solution until the problem is fully understood.
If you do have a budget to hire someone to do this correctly, contact Tom Young: email@example.com