Obviously good gain structure first, but I find Sending the direct out channels PRE EQ also helps quite a bit , especially for vocals , the signal source comes through full range like this obviously. If they want to sculpt the tone they have eq capability per channel on the p16 for that. I send stems and bus mixes post fader / post eq I find that works well also.
Hope that helps!
In 20+ years of sound reinforcement, I have never found any situation where no EQ for monitors - sending pre-EQ as you are describing - was better than sending the FOH EQ to monitors. Vocal mics always need a high-pass filter at least, and usually another band or two. Sending a flat-EQ version will have a bunch of mud to cloud the mix, and most acoustic guitars will need work around 1.7KHz.
In a couple rare cases I have had talent requesting slightly different EQ in the wedge for their mic, but that is a very specific situation for a single channel, and easily accomplished by splitting an input to two channels.