My only complaint about the iNuke series is the fact that the Nu6000 DSP in my friend's club exhibits a profound power off pop if mains power is disconnected when the amp's power switch is in the on position. All the other models I have used and tested do not do this. A quick search seems to suggest that this issue is unique to the 6000DSP model. YMMV.
How is the noise floor on the DSP version? I heard when they first came out that the DSP version was a lot noisier than the non-DSP ones, so I only have the latter. Out of about 20 amps of the NU4's, I've only had one die. We were using it at a gig and it just quit. One channel in use, one monitor connected, not very loud. Plugged in spare and all was good.
They sound great, are very light, and are otherwise reliable IME.
If the OP needs only 2 channels of more power than 300 watts, just get the 2 channel one. It's got the same guts as the 4 channel but has the two pairs of internal channels permanently bridged. It's a little cheaper than the 4 channel one, IIRC.