Ok, I'm running a very similar setup for multitracking(probably just the computer is different). As Brad said make sure you get the correct drivers from Mackie's website and make sure you have the interface selected in Reaper. I'll be setting my rig up tonight for a youth rally that my band is playing at and I'll try and grab some pics of my settings(the laptop I use is kept with the mixer and just used for recording); the settings on my MacBook that I'm on now look completely different and wouldn't be very useful.
Thanks! I have a desktop computer dedicated to just the sound too. It is running Windows 7, 32 bit. I just read an article online this morning that said that I need to change the computer's firewire driver to the "Legacy" version and that this will solve many such issues in win 7. I am going to try and run over to the church on my lunch break and give it a try. I did download the Mackie driver for my mixer. The ASIO shows up as the Mackie in my Reaper settings menu.
Well I forgot to grab those screenshots but you should be able to select the Mackie ASIO driver and make sure the range if inputs is covering all the channels(1-16 are the mono channels and 17-18 is the stereo main mix). After you get the device setup on each channel(see pic) hit the arrow to open the menu and on Input: Mono you should have 18 channels to choose from; pick the channel you want for each track also you can hit Input: Stereo and select a stereo pair of channels if needed.Let me know if this gets you going.Edit: Note: The screenshot was taken on a Mac so the Windows version may look slightly different but should be close enough. Also I'm on the Default theme and Reaper 4.402.
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